Letters to the Editors
نویسندگان
چکیده
We have to report (to our considerable embarrassment) a systematic error which has occurred in a series of papers that have appeared in the British Journal of Nutrition. The relevant papers and faults are shown separately. The mistakes arose as a consequence of a calculation error in the determination of blood flow in muscle. The method used was originally described by Pappenheimer & Setchell(l972). The method depends on infusing tritiated water at an exponentially decreasing rate and measuring the area under the arterio-venous (A-V) difference curve, which is compared with the final value attained. In the method as originally described, for measuring brain blood flow, samples of blood were obtained at I-min intervals and areas were obtained by arithmetically summing each minute’s A-V value. When this method was transferred to study muscle, in which blood flow is much slower than in brain, sampling was made at 2-min intervals. It was assumed that the area would be obtained in the same way. What was in fact obtained was the flow in ml/g per 2 min: blood flow was thus just double what it should have been. Fortunately the mistake has not had a major effect on the conclusions we drew. The new values, however, are much more in line with those obtained elsewhere (see, for example, Oddy et al. 1981). We should emphasize that the referees who examined our publications could not reasonably be expected to detect this error. Since muscle blood flow is highly variable the values could hardly be regarded as inherently unlikely. The mistake was discovered by a visitor to the laboratory, Mr V. H. Oddy, who routinely used the method with a different sampling time. We offer our apologies to the Journal and to readers who may have been misled.
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